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diagnosis rheumatology vasculitis differential classification algorithm cryoglobulins druginduced erythematosus glomerulonephritis management progressive rapidly rpgn systemic table types vasculitides
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Post-strep GN, Lupus ... Nephritis, Cryoglobulinemia ... (C-ANCA): GPA > ... differential #diagnosis #algorithm ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
+MPO) • Cryoglobulinemic ... inflammation Others: • Lupus ... such as systemic lupus ... Low levels mixed cryoglobulinemia ... vasculitis, and SLE
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... to 1:1 F:M • Clinical ... 40, F:M 9:1 • Clinical ... #sle #comparison ... #table #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... diseases: - 10% SLE ... DDX: • ANCA (Antineutrophil ... (e.g. systemic lupus ... erythematosus (SLE
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... macular, patchy eruption ... Diagnosis: • ANCA-associated ... lymphoproliferative syndrome Clinical
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... Elevated ESR and CRP GCA ... develop in pts with GCA ... bullous or vesicular eruption ... + MPO) Cryoglobulinemic
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