Erythematous Rash Differential neurology clinical systemic classification arthritis vasculitis algorithm cryoglobulinemia sle syndrome antinuclear antibodies

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Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

Antinuclear Antibodies ... likely it will be clinically ... Syndrome (SS), ... (SLE), Systemic ... rheumatology #diagnosis #differential

Cryoglobulinemia Summary

Cryoglobulins:
• Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below

activate the immune system ... Syndrome: • Clinical ... lupus erythematosus ... syndrome) #Cryoglobulinemia ... diagnosis #types #classification

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

SLE (Systemic Lupus ... Suspect: Clinical ... Skin Disease Classification ... rash • Erythematous ... permanent alopecia Differential

Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
•

mucositis - Rash ... lupus erythematosus ... C-ANCA) pattern: antibodies ... , and SLE) • Urinalysis ... #rheumatology #classification

Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,

Vasculitis - Differential ... diseases, such as SLE ... ischemia • Skin: Erythematous ... , mucositis • Rash ... / ANCA + MPO) Cryoglobulinemic

Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease

overlaps with RA, SLE ... ab • RF • Antinuclear ... salivary ducts Clinical ... 7%, Cryoglobulinemia ... Arthralgia and Arthritis

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