11 results
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic ... Alkalosis - Differential ... (late) • High Urine ... , Gitelman Syndrome ... Diagnosis #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Alkalosis - Differential ... (late) • High Urine ... , Gitelman Syndrome ... Diagnosis #Algorithm #Nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Metabolic Alkalosis ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... #Metabolic #Alkalosis ... #Algorithm #nephrology
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Hypomagnesemia - Metabolic ... Alkalosis - Elevated ... Renin Urine Testing ... #Workup #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Syndrome is a rare ... → Hypokalemia Metabolic ... alkalosis - ... #nephrology #diagnosis
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic ... volume contracted: urine ... volume expanded: urine ... furosemide-like lesion) • Gitelman ... Diagnosis #Causes #nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
A urine K/Cr ratio ... • Diarrhea A urine ... Alkalosis: Emesis ... , Gitelman syndrome ... differential #potassium #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Alkalosis - Differential ... (late) • High Urine ... , Gitelman Syndrome ... Diagnosis #Algorithm #Nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... alkalosis • Normal ... Hypochloremic metabolic ... (spot urine, calcium-creatinine ... #nephrology #management
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
Workup for Hypophosphatemia ... leukemia Measure Urine ... Glucose, Acute resp. alkalosis ... Diagnosis #Framework #Workup ... #phosphate #nephrology