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diagnosis hematology management oncology leukemia signs agglutinin aplastic chronic classification cll cold cushings cytokine disease endocrinology hemolytic hhv8 hodgkins hypercortisolism
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Clinical Presentation ... and petechiae Causes ... • Improve the symptoms ... #oncology #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... • Diagnostic Test ... Donath-Landsteiner test ... #hematology #diagnosis
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
increased B-cell activity ... renal failure Clinical ... are not caused ... anterior/posterior MSK ... : (distinct symptoms
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Tyrosine Kinase activity ... -> AML: Blast crises ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... Orange or Hep C Clinical ... with no early symptoms ... • Neutropenia, anemia ... • Richter’s Syndrome
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features 1) Skin • Thin, easily bruisable skin with
Cushing's Syndrome ... Diagnosis and Clinical ... , oral cavity) Caused ... dexamethasone suppression test ... Diagnosis #signs #symptoms
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... Weight loss • Anemia ... Immune hemolytic anemia ... ingestion • B symptoms ... • PET scan - activity
KSHV Inflammatory Cytokine Syndrome (KICS) Working Case Definition for KICS: Requires at least 2 clinical manifestations (from
Inflammatory Cytokine Syndrome ... KICS) Working Case ... Symptoms: Fatigue ... abnormalities: Anemia ... of KSHV viral activity
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