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diagnosis hematology oncology differential generalized product pruritus reactions secondary systemic leukemia mds myelodysplasia myelodysplastic primary syndromes transfusion transfusions
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Headaches • Pale skin ... and petechiae Causes ... #management
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
/ Systemic == Blood ... renal failure/uremia ... Myelodisplastic syndrome ... #generalized #dermatology ... #causes
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... just beneath the skin ... that are caused ... • Anemia • Aplastic ... #diagnosis #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary Skin ... Blood Glucose ... Myelodisplastic syndrome ... #generalized #dermatology ... #causes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Tyrosine Kinase activity ... -> AML: Blast crises ... - infiltrates (anemia ... • Tumor lysis syndrome ... CLL -> Invade Skin
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
maculopapular rash ... due to marrow aplasia ... infections with skin ... Transfusion #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
maculopapular rash ... due to marrow aplasia ... infections with skin ... Transfusions #diagnosis #management ... #hematology #reactions
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