4144 results
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's Disease ... CRP, AST+ALT, ferritin ... AOSD: F>M, low ferritin ... AdultOnset #Stills #Disease ... rheumatology #diagnosis #management
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Onset Still's Disease ... • ↓Hgb • High ferritin ... the higher the ferritin ... onset #Stills #disease ... #rheumatology #management
Gastrointestinal Evaluation of Iron Deficiency Anemia
In patients with anemia, diagnose iron deficiency if:
 • Ferritin <
deficiency if: • Ferritin ... Test for celiac disease ... change medical management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
dysfunction, ↑ Ferritin ... • Autoimmune diseases ... Adult-onset Still disease ... Lymphohistiocytosis #diagnosis #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
highly inflammatory disease ... Adult-onset Still disease ... of underlying disease ... dehydrogenase • ↑ Ferritin ... Syndrome #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... cell activity • Ferritin ... Lymphohistiocytosis #diagnosis #management
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. 

Step 1: In the patient with
causes of liver disease ... concentration; SF, serum ferritin ... algorithm #diagnosis #management
Diagnostic Schema for Hyperferritinemia

Pearl: Diseases associated with extreme elevations: 
1. HLH 
2. Still's disease 
3. Systemic
Hyperferritinemia Pearl: Diseases ... Still's disease ... histoplasmosis #Ferritin
Iron Panel Interpretation

Iron deficiency - ↓ Iron, ↑-nl Transferrin / TIBC, ↓ Transferrin Saturation,  ↓
Saturation, ↓ Ferritin ... Saturation, ↑-nl Ferritin ... Saturation, ↓-↑-nl Ferritin ... Saturation, ↑-nl Ferritin
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Increased Serum Ferritin ... number of sites of disease ... hematology #oncology #management