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diagnosis hematology differential management algorithm clinical treatment causes anemia video msk physicalexam workup vasculitis lupus syndrome disease pathophysiology table thrombocytopenia
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
CRP, AST+ALT, ferritin ... AOSD: F>M, low ferritin ... Disease #AOSD #rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
granulocytes • Ferritin ... • ↓Hgb • High ferritin ... the higher the ferritin ... AOSD #diagnosis #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
dysfunction, ↑ Ferritin ... treatment #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
dehydrogenase • ↑ Ferritin ... Diagnosis #Management #Hematology ... #Rheumatology
Iron Panel Interpretation Iron deficiency - ↓ Iron, ↑-nl Transferrin / TIBC, ↓ Transferrin Saturation, ↓
Saturation, ↓ Ferritin ... Saturation, ↑-nl Ferritin ... Saturation, ↓-↑-nl Ferritin ... Saturation, ↑-nl Ferritin ... #differential #hematology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
Ferritin levels ... Dermatomyositis #rheumatology
Diagnostic Schema for Hyperferritinemia Pearl: Diseases associated with extreme elevations: 1. HLH 2. Still's disease 3. Systemic
histoplasmosis #Ferritin ... Differential #Diagnosis #Hematology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... TSH level, serum ferritin ... diagnosis #testing #Rheumatology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Globin Synthesis Ferritin ... Dietary Deficiency) Ferritin ... Inflammation Ferritin ... Algorithm #Causes #Hematology
Iron Deficiency Anemia (IDA) Tests: • MCV/RBC - RBC ↓ in proportion to the ↓ in hemoglobin
synthesis • Ferritin ... #Anemia #IDA #ferritin ... Fe #diagnosis #hematology
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