6 results
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... hemoglobinuria) • Cold Agglutinin ... #Hemolytic #Anemia ... Diagnosis #Table #hematology
Janeway Lesions: Flat, painless, erythematous lesions seen on the palm of this patient's hand. Frequently
associated with
Janeway Lesions: ... with bacterial endocarditis ... Photo credit, Josh Fierer ... Clinical #Photo #Dermatology ... #SkinRash #Janeway
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral infection, autoimmune ... nose, ears, or fingers ... anemia • Cold ... CLL (older) • Autoimmune ... #anemia #hematology
Janeway Lesion: Flat, painless, erythematous lesions seen on the palm of this patient's hand. While
frequently associated
Janeway Lesion: ... with bacterial endocarditis ... Photo credit, Josh Fierer ... Clinical #Photo #Dermatology ... #SkinRash #Janeway
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... Immune-mediated: - Autoimmune ... idiopathic) - Autoimmune ... . primary cold agglutin ... #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold agglutinins ... elliptocytosis, autoimmune ... #Anemia #Differential ... Algorithm #workup #hematology