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diagnosis rheumatology agglutinin algorithm approach causes chronic cold disease erythematosus gap globulin gravis hemolytic joint lupus management mds msk myasthenia
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
- Differential ... Neoplastic / Hematologic ... • Anemia • ... • Rheumatoid Arthritis ... • Somatization Disorder
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
• Weakness • Fatigue ... -60 minutes or longer ... - Fatigue is ... #approach #workup ... #differential #
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
nose, ears, or fingers ... • Symptoms of anemia ... include fatigue ... younger pts) Differential ... #hematology #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Clinical evidence of (fatigue ... permanent alopecia Differential ... Malignancy (e.g. hematologic ... ) • Endocrine disorders ... lymphopenia, low PLT • Anemia
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
an autoimmune disorder ... syndrome, rheumatoid arthritis ... life-threatening Differential ... - Generalized fatigue ... immunosuppressants - Meds
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Symptoms: • Fatigue ... blood count with differential ... Syndromes #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Connective tissue disorders ... (RA, Temporal arteritis ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential
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