4 results
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
(AIHA) - Differential ... -70%) Cold AHA ... Agglutinin Disease ... #AIHA #Differential ... #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin ... Cold Agglutinins ... women • 15% of AIHA ... nose, ears, or fingers ... • Cold agglutinin
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
)"Cold" (usually ... (e.g. primary cold ... agglutin disease ... Extravascular #Causes #differential ... #anemia
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Coagulopathy) SMZL: • AIHA ... (-) hemolytic anemia ... due to cold IgG ... Paraproteinemias #Hematology ... #Monoclonal #Differential