21 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... uremic syndrome ... Autoimmune (AIHA)"Cold ... . primary cold agglutin ... Extravascular #Causes #differential
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Valves, AS - HTN ... Autoimmune: Warm AIHA, Cold ... Drug-associated, PCH, Evans Syndrome ... Diagnosis #hematology
Raynaud's Syndrome - Washing off under hot water.
Raynaud phenomenon is an exaggerated vasoconstrictive response of the
Raynaud's Syndrome ... and arterioles (e.g ... and/or toes) to cold ... #disease #phenomenon ... #hands #rheumatology
Raynaud's Syndrome - Washing off under hot water wath.

Raynaud phenomenon is an exaggerated vasoconstrictive response of
Raynaud's Syndrome ... and arterioles (e.g ... and/or toes) to cold ... #disease #phenomenon ... #hands #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Agglutination - Cold ... #Anemia #Differential ... Diagnosis #Algorithm #workup ... #hematology #testing
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Agglutinin Syndrome ... nose, ears, or fingers ... younger pts) Differential ... #hemolytic #anemia ... #hematology #diagnosis
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Chemotherapy (e.g ... Cell Agglutinate: Cold ... anemia, Paroxysmal cold ... RBC #Morphology #differential ... #diagnosis #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
for workup, including ... blood loss, Acute hemolysis ... Inflammatory Conditions: Rheumatologic ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome
Primary and Secondary Causes of Hypertension - Differential Diagnosis Algorithm
Primary (Essential) (95%) - Onset between age
Hypertension - Differential ... taken at home, work ... excess (Cushing syndrome ... Primary #Secondary #HTN ... #Cardiology #Differential
Hypertensive Disorders of Pregnancy
Chronic Hypertension:
 • Guidelines as SBP ≥130 or DBP ≥ 90 mmHg
 •
And Proteinuria (e.g ... patients • HELLP: Syndrome ... of hemolysis, elevated ... #obstetrics #cardiology ... #differential #