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IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis in Human Immunodeficiency Virus Infected Individuals
Induction therapy:
 • AmBd (0.7–1.0
Recommendations for Cryptococcal ... • AmBd plus fluconazole ... • Fluconazole ... week) >1 year #Cryptococcal ... management #meningitis #cryptococcus
Important Fungal Stains
Mycology Lab:
 • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
preparation from culture Pathology ... polysaccharide capsule of Cryptococcus ... detection for cryptococcal ... mucopolysaccharide capsule of Cryptococcus ... cell walls of Cyptococcus
Fungal Pneumonias - Diagnosis Comparison Table
 • Aspergillus
 • Blastomyces
 • Candida
 • Coccidioides
 • Cryptococcus
Coccidioides • Cryptococcus ... infectiousdiseases #pathology
Cryptococcus neoformans Meningoencephalitis- The opening pressure on lumbar puncture was 29 cm of water (reference range,
Cryptococcus neoformans ... The cryptococcal ... CSF culture grew Cryptococcus ... clinical #NEJM #Cryptococcus ... stain #indiaInk #pathology
Spectrum of activity for systemic antifungal agents
Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
caspofungin; FLU, fluconazole ... Aspergillus fumigatus, Cryptococcus
Antifungal Azoles - Antibiotics Class Overview

Mechanism:  inhibit ergosterol synthesis (important component of fungal cell membranes)
- Only Fluconazole ... Fluconazole(PO or ... Azoles #Antifungal #Fluconazole
IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis in Transplant Recipients
Induction therapy:
 • liposomal AmB (3–4 mg/kg per
Recommendations for Cryptococcal ... Consolidation therapy: fluconazole ... Maintenance therapy: fluconazole ... year B-III #Cryptococcal ... management #meningitis #cryptococcus
Common Fungal Pathology 
 • Candida - Small yeast intermingled with pseudohyphae
 • Aspergillosis - Septate
Common Fungal Pathology ... broad based bud • Cryptococcus ... ucsdim #Fungal #Pathology
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases

Acanthocyte (spur cell),  
Basophilic stippling, 
Bite cell,
Pathologic Red Blood ... Atlas #Microscopy #Pathology ... Robbins & Cotran Pathologic
Morphology and Descriptions of Endemic Fungal Infections with Yeasts in Tissues
Broad-based budding yeasts:
 • Description: Broad-based
, Histoplasma, Cryptococcus ... Consistent with Cryptococcus ... capsule deficient Cryptococcus ... morphology #yeasts #pathology