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hematology differential management oncology pancytopenia algorithm aplastic causes cobalamin erythematosus lupus mds myelodysplasia myelodysplastic neutropenia signs sle symptoms syndromes systemic
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... Vitamins and Vitamin Deficiency ... gestation • Vitamin B12 ... #differential #diagnosis ... signs #symptoms #nutrition
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
- Differential Diagnosis ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... • Fanconi’s anemia ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12 ... #Hematology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... Present in foods ... intrinsic factor, IF) Clinical ... #Cobalamin #Deficiency ... #nutrition
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... , GATA2 deficiency ... , CTLA4 deficiency ... #oncology #hematology ... #diagnosis #management
Etiologies of Vitamin B12 Deficiency • Inadequate intake - Rare but seen in very strict vegans
Deficiency • Inadequate ... deficiency. ... autoantibodies (pernicious anemia ... #differential #diagnosis ... #hematology #nutrition
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Platelet Disorders • Nutritional ... : vitamin B12 or ... folic acid deficiency ... treatments • Copper deficiency ... Myelodysplastic #Syndromes #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... disease • Prolidase deficiency ... spares nasolabial folds ... lymphopenia, low PLT • Anemia ... #Rheumatology
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