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diagnosis algorithm causes hemolytic liver workup hemolysis transaminitis extravascular injury intravascular oncology abnormal alkaline alp anemias anorexianervosa b12 chemistry cholestatic
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... - Differential ... Membrane defects, Enzyme ... #Differential # ... Diagnosis #Algorithm #hematology
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Causes of Hemolytic Anemia ... - Differential ... Hemoglobin - Enzyme ... #Differential # ... Diagnosis #Causes #hematology
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Anemia - Underproduction ... Iron deficiency anemia ... disorder - TSH, LFTs ... Underproduction #Algorithm #hematology ... #diagnosis #differential
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... AnnKumfer #Liver #Enzymes ... #LFTs #Hepatocellular ... Transaminitis #diagnosis #differential ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Others #LFTs ... #Hepatology #LiverEnzymes ... #Differential #
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... Intrinsic Causes: • Enzyme ... #Differential # ... classification #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... , Spiders - Enzyme ... Defects: Sickle cell anemia ... #Hemolysis #Differential ... #Diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis - Differential ... elliptocytosis - RBC Enzyme ... immune-complex hemolytic anemia ... Extravascular #Differential ... Algorithm #Causes #Hematology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
normal - Hemolysis, NASH ... Liver #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... deficiency, Other enzyme ... #Differential # ... Algorithm #workup #hematology
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