4 results
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
Pathogenesis and Clinical ... infections • Clinical ... lectin pathway activation ... and meninges -> Activation ... Maculopapular rash
Humoral Immunity - Pathogenesis and Clinical Findings
Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
Pathogenesis and Clinical ... triggering their activation ... enhance B cell activation ... Activation slide ... cells are long-lived
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... fever syndromes Clinical ... Fever is the main clinical ... thrombocytopenia • Liver ... #Macrophage #Activation
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... anti-Smith Ab, low complements ... lymphoproliferative syndrome Clinical ... RNP antibodies, Complement ... Chronic B-cell activation