53 results
Hypercortisolism (Cushing syndrome) - Simplified Differential Diagnosis Algorithm
Exogenous (ACTH-independent)
Endogenous
 • ACTH-dependent:
    - ACTH-secreting
) - Simplified Differential ... : - Adrenal ... hyperplasia - Adrenal ... Cushings #syndrome #Differential ... Diagnosis #Algorithm #endocrinology
Adrenal Insufficiency Differential Diagnosis Algorithm
Clinical suspicion: Weakness, fatigue, nausea, musculoskeletal pain, dizziness, volume depletion, abdominal pain,
Differential Diagnosis ... Baseline plasma ACTH ... High baseline ACTH ... Insufficiency #Differential ... Diagnosis #Algorithm #endocrinology
Adrenal Insufficiency - Differential Diagnosis Workup Algorithm
Primary Adrenal Insufficiency:
 • Autoimmune primary adrenal insufficiency
 • Adrenoleukodystrophy,
Adrenal Insufficiency ... - Differential ... apoplexy • Isolated ACTH-deficiency ... Insufficiency #Differential ... Workup #Algorithm #endocrinology
Causes of Adrenal Insufficiency - Differential Diagnosis Algorithm
ACTH-Dependent (Secondary):
 • Pituitary Dysfunction
 • Hypothalamic Dysfunction
ACTH-Independent (Primary):
Insufficiency - Differential ... Diagnosis Algorithm ACTH-Dependent ... Hypothalamic Dysfunction ACTH-Independent ... Insufficiency #AI #Differential ... Algorithm #Causes #endocrinology
Diagnosis Adrenal Insufficiency - Algorithm

Step 1) Screening Test: 6-8AM Cortisol Level
 - Early morning cortisol levels
Diagnosis Adrenal ... determines if the adrenal ... Step 3) Differentiate ... gland) #Adrenal ... #Stimulation #Endocrinology
Benign Adrenal Mass - Differential Diagnosis Algorithm
Hyperplasia - Often Bilateral
 • Congenital Adrenal Hyperplasia
 • ACTH
Benign Adrenal Mass ... - Differential ... Hyperplasia • ACTH ... Dependent • ACTH ... Diagnosis #Algorithm #Endocrinology
Primary vs Secondary Adrenal Insufficiency - Pathophysiology
Primary AI = adrenal glands themselves are the problem. This
Primary vs Secondary Adrenal ... be low, while ACTH ... Low ACTH leads to ... limited adrenal ... Pathophysiology #endocrinology
Adrenal Insufficiency Diagnosis Algorithm - Evaluation of HPA Axis Response to ACTH

Early am cortisol < 3
Adrenal Insufficiency ... Axis Response to ACTH ... indicates normal adrenal ... tertiary AI #Adrenal ... Stimulation #Test #Endocrinology
Primary Adrenal Insufficiency:
 • ACTH stimulation test - Synthetic ACTH does not stimulate cortisol secretion because
Insufficiency: • ACTH ... test - Synthetic ACTH ... by endogenous ACTH ... Low • Plasma ACTH ... diagnosis #testing #endocrinology
Primary Adrenal Insufficiency
Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
AM cortisol and ACTH ... AI present - ACTH ... Administer 250 mcg ACTH ... AI present - ACTH ... addisons #disease #endocrinology