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hematology oncology differential arthritis leukemia pain chronic classification disease erythematosus hodgkins laboratory lymphoma management mds monoclonal myelodysplasia myelodysplastic paraproteinemias rheumatic
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
ALL Symptoms: ... bone pain, fever, joint ... - infiltrates (anemia ... CLL Symptoms: • ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... • Neutropenia, anemia ... aplasia • ITP ... #workup #oncology ... #hematology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Approach to Joint ... spondyloarthropathies, lupus ... #Joint #Pain #MSK ... #rheumatology # ... approach #workup
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
Approach to Joint ... or nerve root Symptoms ... #Pain #MSK #rheumatology ... #approach #workup ... #differential #diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Scleromyxedema (CNS+GI+CVS+joints ... (-) hemolytic anemia ... to cold IgG • Lupus ... #Differential #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Arthritis: • Joint ... lymphopenia, low PLT • Anemia ... : • Symptoms limited ... #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... • Progressive symptoms ... elevated protein, lymphocytic ... Palpable purpura, joint ... #Rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... age 70 years Symptoms ... • Aplastic Anemia ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... Weight loss • Anemia ... Immune hemolytic anemia ... ingestion • B symptoms ... Hodgkin Lymphoma Workup
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... • Systemic lupus ... the presence of anemia ... #diagnosis #testing ... #Rheumatology
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