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hematology management chronic cll differential leukemia lymphocytic mgus cell classification gammopathies gammopathy gap globulin hemeonc hodgkins lymphoma mds multiplemyeloma myelodysplasia
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma and Monoclonal ... 40 ml/min A - Anemia ... amyloidosis, solitary plasmacytoma ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Can Feature A Monoclonal ... (-) hemolytic anemia ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... • Improve the symptoms ... #Anemia #oncology ... #hematology #diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... fludarabine) 3) Monoclonal ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
No evidence of anemia ... constitutional symptoms ... insufficiency, Anemia ... #Significance #hematology ... #diagnosis #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... • Neutropenia, anemia ... Pure red cell aplasia ... #workup #oncology ... #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... tissue composed of monoclonal ... • No CRAB - no anemia ... #Oncology #Diagnosis ... #Workup #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... age 70 years Symptoms ... • Aplastic Anemia ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... leukemia • Solitary plasmacytoma ... syndrome) • Solitary plasmacytoma ... Thalassemia, Sickle cell anemia ... #differential #diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immune hemolytic anemia ... ingestion • B symptoms ... Hodgkin Lymphoma Workup ... #oncology #management
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