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diagnosis differential vasculitis allergy hypersensitivity joint management msk reactions syndrome table workup antibodies approach comparison cryoglobulinemia cryoglobulins disease erythematosus hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... assay (IFA) is the main ... Juvenile Idiopathic Arthritis ... @AnnKumfer #Antinuclear ... #patterns #rheumatology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antibodies bind to mast ... degranulation of mast ... glomerulonephritis, rheumatoid arthritis ... , and systemic lupus ... #Classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Skin Disease Classification ... Kikuchi disease • Type-I ... : • Joint pain ... Chronic B-cell activation
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... • Fever is the main ... SJIA], systemic lupus ... erythematosus [SLE ... #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
arthritis) • ... Types II and III ... (e.g. systemic lupus ... #classification ... #rheumatology #
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Allergen-specific lgE causes mast-cell ... to complement activation ... Examples: Rheumatoid arthritis ... glomerulonephritis, Systemic lupus ... allergy #table #classification
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
non-activity, may ... - Autoimmune Rheumatologic ... • SLE • Psoriatic ... Symmetrical: • RA • SLE ... Diagnosis #MSK #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... ) - Antinuclear ... Tests for All Types ... low back pain)
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
SLE, atherosclerotic ... tract: Abdominal pain ... involvement, abdominal pain ... and GN Anti-GBM ... Differential #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... systemic lupus ... SLE) • Urinalysis ... differential #diagnosis #rheumatology ... #classification
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