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diagnosis differential classification cardiology cryoglobulins glomerulonephritis hematology isolated neutropenia pericarditis progressive rapidly rpgn sjogrens syndrome types vasculitides
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Complement: Post-strep GN ... , Lupus Nephritis ... , Cryoglobulinemia ... #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... arthralgia, and arthritis ... (e.g. systemic lupus ... classification #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... tract, and often causes ... ANCA +MPO) • Cryoglobulinemic ... such as systemic lupus ... differential #diagnosis #rheumatology
Causes of Pericarditis - Differential Diagnosis Algorithm Viral: • Coxsackie • Echovirus • Adenovirus • Epstein-Barr virus
Causes of Pericarditis ... • Epstein-Barr virus ... • Rheumatoid arthritis ... • Systemic lupus ... spondyloarthropathies • Vasculitis
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm Congenital Medications • Anticonvulsants • Antibiotics • Antithyroid • Antihypertensive
Causes of Isolated ... • Epstein-Barr Virus ... Destruction • Systemic Lupus ... • Rheumatoid Arthritis ... #Causes #Hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
GCA (Giant Cell Arteritis ... tract, and often causes ... arthritis. ... / ANCA + MPO) Cryoglobulinemic ... Differential #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... Membranoproliferative GN ... : • 7%, Cryoglobulinemia ... Arthralgia and Arthritis ... #Diagnosis #Management
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