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diagnosis classification differential hematology allergy hypersensitivity management reactions table types algorithm ana antinuclear causes comparison disease erythematosus hemeonc hemophagocytic hlh
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... lupus erythematosus ... • Fever is the main ... Diagnosis #Management #Hematology ... #Rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... assay (IFA) is the main ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Allergen-specific lgE antibodies ... - Local and systemic ... Complement activation ... glomerulonephritis, rheumatoid arthritis ... , and systemic lupus
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm Congenital Medications • Anticonvulsants • Antibiotics • Antithyroid • Antihypertensive
• Epstein-Barr Virus ... Destruction • Systemic ... Lupus Erythematosus ... • Rheumatoid Arthritis ... Algorithm #Causes #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... : • Joint pain ... 1, SCL-70, RNP antibodies ... Chronic B-cell activation
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Action: IgG/lgM antibodies ... to complement activation ... glomerulonephritis, Systemic ... lupus erythematosus ... T-cells recruit macrophages
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... inflammation Others: • Lupus ... lupus erythematosus ... C-ANCA) pattern: antibodies ... differential #diagnosis #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... affected joint • Systemic ... lupus erythematosus ... double-stranded DNA antibodies ... , and low back pain
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
of the immune system ... termed MAS-HLH: Macrophage ... Activation Syndrome ... inhibitors, anti-IFN-γ antibodies ... Diagnosis #Management #Hematology
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