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diagnosis differential erythematosus symptoms syndrome systemic joint vasculitis workup activation ana antibodies antinuclear approach autoantibodies behcet classification hematology laboratory macrophage
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
of hip (rare), Arthritis ... lesions Abdominal pain ... (20%) Renal disease ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
assay (IFA) is the main ... Juvenile Idiopathic Arthritis ... : Lupus (SLE), Systemic ... Sjögren Syndrome, Myositis ... ANA #patterns #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Manifestations: - Arthritis ... anemia 4% - Myositis ... Lupusreference #SLE ... autoantibodies #signs ... #differential #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
noninflammatory Signs ... • SLE • Psoriatic ... #Diagnosis #MSK ... #rheumatology # ... Monoarticular #Monoarthritis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... : • Joint pain ... • Transverse Myelitis ... Erythematosus #Diagnosis #Rheumatology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
spondyloarthropathies, lupus ... Joints Involved: Monoarticular ... Chronic = RA, SLE ... #Joint #Pain #MSK ... #rheumatology #
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
: SLE, Reactive ... Nonsurgical abdominal pain ... Syndrome #diagnosis #management ... #signs #symptoms ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, such as SLE, atherosclerotic ... purpura: Strong sign ... tract: Abdominal pain ... involvement, abdominal pain ... Differential #Diagnosis #Rheumatology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
or without back pain ... • Bilateral signs ... Evaluate for NMO, SLE ... Disorders: - SLE ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... • Fever is the main ... erythematosus [SLE ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
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