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management reactions classification hematology product differential druginduced hypersensitivity pathophysiology sle transfusion transfusions types vasculitides vasculitis
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Red blood cell ... during hemolytic disease ... systemic lupus ... #Diagnosis #Reactions ... #Table
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Workup: - ANA ... Evolution: Chronic disease ... #sle #comparison ... #table #rheumatology ... #diagnosis #management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... Others: • Lupus ... Large Vessel: Blood ... LFT • ESR • ANA ... #rheumatology #
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
- Allergic ... transfusion related death ... Borrellia (Lyme disease ... #Transfusions #diagnosis ... #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
• Allergic reaction ... transfusion related death ... anti-HLA or anti-HNA ... #Transfusion #diagnosis ... #management #hematology
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