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diagnosis oncology cancer differential emergencies leukemia management oncologic syndrome tls tumor
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... - 80% have fever ... - ACS, AKI, acute ... Treatment: - If febrile ... diagnosis #management #hematology
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Diagnosis Framework HEMATOLOGIC ... Leukostasis: • ... death Neutropenic Fever ... EMERGENCIES: Tumor Lysis ... Hyperuricemia • Acute
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... Headaches, bone pain, fever ... ↑ Can develop leukostasis ... & DIC • Tumor lysis ... #Leukemia #Hematology
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