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diagnosis management treatment hematology hemophagocytic hlh latenttb lymphohistiocytosis rheumatology tb tuberculosis neurology physicalexam active amyloid amyloidosis burnflux cirrhosis clarkes comatose
Clarke's Test (Patellar Grind Test) Indicates Patellofemoral dysfunction. - Patient with knee in extension. Push posterior on
Clarke's Test (Patellar ... Grind Test) ... Patellofemoral dysfunction ... patient to perform active ... Patellar #Grind #clinical
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 Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Active: Symptomatic ... • Endogenous reactivation ... characteristic features Clinical ... Tuberculin skin test ... Inhibitor: • Risk of reactivation
Tuberculosis Testing LATENT TB • LTBI is diagnosed when an asymptomatic patient has a positive TST or IGRA
result with no clinical ... manifestations of active ... decrease the risk for reactivation ... of developing active ... years of age ACTIVE
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Active: Symptomatic ... • Endogenous reactivation ... characteristic features Clinical ... Tuberculin skin test ... Inhibitor: • Risk of reactivation
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... accumulation of clinical ... Assessment • Clinical ... , Hb), Hepatic dysfunction ... inhibitors under evaluation
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
Preoperative Risk Evaluation ... Performance thorough ... determine if stress test ... or LV dysfunction ... Change in clinical
The Neurological Evaluation of a Comatose Patient Definition: • Coma: a state of unresponsiveness; the absence of
The Neurological Evaluation ... Severe injury/dysfunction ... ascending reticular activating ... Test downward eye ... Test if patient
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
bowel or bladder dysfunction ... • Excessive activation ... Transverse Myelitis - Clinical ... negative, MOG-IgG test ... Herpes zoster, West
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... fever syndromes Clinical ... Fever is the main clinical ... nervous system (CNS) dysfunction ... Liver function tests
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... excessive macrophage activation ... genetic immune dysfunction ... absent NK cell activity
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