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diagnosis hemophagocytic hlh lymphohistiocytosis management perioperative preop preoperative rheumatology risk stratification summary treatment
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... , Hb), Hepatic dysfunction ... Drugs, Unknown cause ... Etoposide/VP16 (100 mg/m2 ... inhibitors under evaluation
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
Preoperative Risk Evaluation ... or family - Ever ... Performance thorough ... event, follow ACC algorithm ... or LV dysfunction
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