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anemia differential hemolytic agglutinin betadglucan biomarkers causes comparison disease evaluation fungal galactomannan immunecompromised immunocompromised perioperative preop preoperative risk stratification workup
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Positive Coombs testing ... post infectious setting ... temperatures by fixing complement ... Symptoms: High fevers ... hemolytic #anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Algorithm • Sickle ... Agglutination - Cold ... bartonella (oroya fever ... #hematology #testing
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
infection (IFI) in hematologic ... concurrent admin of mold-active ... post-2010 almost never ... Frozen ice-pops (in setting ... Galactomannan #diagnosis
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Algorithm Structural ... Pneumonia • Aspergillus ... Periodontal Disease Complement ... #Hematology
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
or family - Ever ... Performance thorough ... event, follow ACC algorithm ... surgery Stress Testing ... stratification #diagnosis
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