42 results
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... changes, stroke symptoms ... Lysis Syndrome: • Pathophysiology ... worrisome EKG features
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... (HLH) Pathophysiology ... Unknown cause Treatment ... Taar #HLH #Hemophagocytic ... diagnosis #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... the disease is also ... HLH signs and symptoms ... • Bicytopenia Treatment ... diagnosis #management #treatment
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
A subset of hemophagocytic ... cytokines, such as ... tests ↑ AST ↑ ALT ... Histopathologic features ... Treatment: • Corticosteroids
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
• recurrent fractures ... adult population: also ... collection with EDTA Pathophysiology ... mineralization Symptoms ... pain - Frequent fractures
Ankylosing Spondylitis: Pathogenesis and Clinical findings
 • Pain in lumbar area and gluteal region: (Dull, insidious
more constant as ... bamboo spine) -> Fracture ... AnkylosingSpondylitis #pathophysiology ... diagnosis #signs #symptoms
Iron Deficiency in Heart Failure
Pathophysiology:
Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation
Heart Failure Pathophysiology ... functional ID) Treatment ... improvement in symptoms ... composite endpoint of all-cause
Non-Infective Endocarditis (NBTE / Marantic Endocarditis)
Non-infective endocarditis is also known as: Non-bacterial thrombotic endocarditis (NBTE), Aseptic
endocarditis is also ... known as: Non-bacterial ... pathognomonic signs/symptoms ... or echo features ... Marantic #diagnosis #pathophysiology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
pattern of spread, B symptoms ... not as common ... Responsive to Treatment ... growth, response to treatment ... Classification #pathophysiology
Emphysematous Cystitis
Epidemiology:
 • Usually middle-aged diabetic women
 • Other RF: neurogenic bladder, urinary tract outlet obstruction,
Clinical Signs/Symptoms ... Pathophysiology: ... Coli, but can also ... Urine cultures also ... data • Early treatment