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differential oncology cvid disease gap globulin hypogammaglobulinemia immunodeficiency immunology lymphocytic mds myelodysplasia myelodysplastic protein proteingap signs symptoms variable vasculitis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... • Richter’s Syndrome ... • Sezary syndrome ... #Leukemia #diagnosis ... #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome ... syndrome (Clinical ... adenopathy (PFAPA) syndrome ... #Syndrome #diagnosis ... #symptoms #rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
: • Nephrotic syndrome ... (Epstein-Barr syndrome ... , HIV) • Glucocorticoid ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... Most common cytopenia ... Marrow Failure • Chronic ... Cell Leukemia ... #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... , HBV, EBV, VZV, ... gastric tumors • Hematology ... : Lymphoma, Leukemia ... #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
HTN • Check: HBV ... Mucocutaneous lymph node syndrome ... syndrome: Recurrent ... vasculitis • Cogan syndrome ... #Rheumatology
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