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differential classification joint oncology vasculitis approach autoimmune behcet common cvid globulin hodgkins hypogammaglobulinemia immunodeficiency immunology leukemia monoarthritis monoarticular myopathy myositis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... infections (acute HIV ... , HBV, EBV, VZV, ... gastric tumors • Hematology ... #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
skin injury) • Neurologic ... , AS Treatment: ... Recurrent and chronic ... #diagnosis #management ... #rheumatology #
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
constitutional symptoms ... weeks) Can Be Caused ... Parvovirus B19 • HIV ... #Diagnosis #MSK ... #rheumatology #
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Nodules • Lymphoid ... DDX - Other causes ... , HIV) • Glucocorticoid ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... activity • ↓ LAP ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Eosinophilia, asthma, chronic ... tract, and often causes ... Cryoglobulins • HIV ... • HBV HCV • ... #rheumatology #
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
ingestion • B symptoms ... Workup: • Full ... Treatment • Early ... #hematology #oncology ... #management
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Approach to Joint Pain ... - parvovirus, HIV ... #Joint #Pain #MSK ... #rheumatology # ... approach #workup
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Nephrogenic DI Hematologic ... phenomenon (16%) MSK ... Arthralgia and Arthritis ... #Rheumatology # ... Diagnosis #Management
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
HTN • Check: HBV ... • Progressive symptoms ... Eosinophilia, asthma, chronic ... tract, and often causes ... #Rheumatology
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