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oncology arthritis agglutinin approach behcet classification cold cvid erythematosus gap globulin hemolytic hodgkins hypogammaglobulinemia immunodeficiency immunology laboratory lupus lymphocytic lymphoma
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... • Neutropenia, anemia ... #CLL #Chronic ... #diagnosis #workup ... #oncology #hematology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Pain - Diagnostic ... - parvovirus, HIV ... #Joint #Pain #MSK ... #rheumatology # ... approach #workup
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... symptoms - most common ... , HIV, rubella legionella ... chills, flank pain ... #hematology #diagnosis
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... autoimmune hemolytic anemia ... , HIV) • Glucocorticoid ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Most common cytopenia ... Marrow Failure • Chronic ... Cell Leukemia ... Myeloproliferative Disease ... #diagnosis #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Zone Lymphoma (HCV ... et diutinum Neurologic ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... infections (acute HIV ... , HBV, EBV, VZV, ... gastric tumors • Hematology ... #diagnosis #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
of age • Most common ... skin injury) • Neurologic ... ) Differential Diagnosis ... #diagnosis #management ... signs #symptoms #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... pain • Swan neck ... common • Antihistone ... with Lupus: • Chronic ... #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... the presence of anemia ... Additional tests: HIV ... , and low back pain ... #Rheumatology
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