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diagnosis algorithm lfts management causes obstetrics oncology pathophysiology pregnancy aplastic biliary cholangitis cirrhosis classification comparison disease elevated enzymes gap globulin
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... of Pregnancy (AFLP ... infiltration) Differential ... #Fatty #Liver # ... Pregnancy #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... NAFLD, Others • Mild ... LFTs #Elevated #Abnormal ... Algorithm #diagnosis #hepatology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
• Histology: Normal-mild ... hemorrhage Acute Fatty ... (AFLP) • Onset ... Disease #Pregnancy #hepatology ... hepatitis #comparison #differential
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Pregnancy - AFLP ... NAFLD • Others Mild ... Others #LFTs #Hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... ALP, alkaline phosphatase ... non-alcoholic fatty ... #Algorithm #Hepatology ... #Differential #
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
syndrome (MDS) (normal ... megakaryocytes and a normal ... Marrow hypoplasia/fatty ... • Allogeneic HSCT ... #oncology #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
result in severe anemia ... immune hemolytic anemia ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
obstruction • ALP ... or higher • Liver ... bile ducts Differential ... cholangitis #diagnosis #workup ... #hepatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... Hb>16.5 g/dL, Hct ... Hb>16.0 g/dL, Hct ... Better call hematology ... #hematology
Anemia of Hospitalization - Pathophysiology Why does the Hgb/Hct drop in the first two days during hospitalization? Interestingly,
Why does the Hgb/Hct ... -6% drop in Hg/Hct ... 30 min and Hg/Hct ... concentrating Hg/Hct ... Decrease of Hg/Hct
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