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diagnosis fungal management treatment aspergillus betadglucan latenttb tb tuberculosis biomarkers comparison falsepositives ia invasive laboratory sensitivity testing
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
TB: • HIV • Recent ... disease • DM DDX ... are pulmonary • HIV ... TST or IGRA HIV ... : • HIV-infected
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
TB: • HIV • Recent ... disease • DM DDX ... are pulmonary • HIV ... TST or IGRA HIV ... : • HIV-infected
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
and Aspergillus Galactomannan ... cut-offs defined in clinical ... admin of mold-active ... Clav (may be + as long ... setting of GVHD) ID
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
SOT, Advanced HIV ... /AIDS, CGD) Clinical ... • Aspergillus Galactomannan ... angle branching • Ddx ... treatment #fungal #infectiousdiseases
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
positives: IVIG, IV ... Spec 81% for dx ... >90% (In most clinical ... concurrent admin mold-active ... result in + as long
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