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diagnosis hematology differential management oncology agglutinin aplastic classification cold common cryofibrinogenemia cryoglobulinemia cryoglobulins cvid disease hemolytic hypogammaglobulinemia immunodeficiency immunology monoclonal
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... : HCV infection, ... HBV infection, ... HIV infection ... classification #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Clinical Presentation ... • Symptoms of anemia ... Mycoplasma, EBV, HIV ... #hematology #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... - CMV - HCV ... - HIV • Immune ... and thymoma DDX ... immunodeficiency virus (HIV
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Avg age of DX ... to 8 years Clinical ... autoimmune hemolytic anemia ... DDX - Other causes ... Epstein-Barr syndrome, HIV
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Direct microbial infection ... Transverse Myelitis - Clinical ... simplex virus, HIV ... - Sjogren - Vasculitis ... diagnosis #management #neurology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
malignancies, vasculitis ... Malignancy • Infections ... Diagnosis: • + Clinical ... Cryofibrinogenemia DDX ... • TTP, HUS and HIT
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
affects the skin, neurologic ... HTN • Check: HBV ... cognitive impairment, neurologic ... drug exposure or Dx ... Differential #Diagnosis #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Zone Lymphoma (HCV ... et diutinum Neurologic ... Autoimmunity: • -MM/WM: Vasculitis ... (-) hemolytic anemia ... due to cold IgG
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