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diagnosis differential hematology management classification disease agglutinin anemia antibody antigens behcet brain cold cryofibrinogenemia cryoglobulinemia cryoglobulins crypto cryptococcal cvid dermatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... : HCV infection, ... HBV infection, ... HIV infection ... classification #rheumatology
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
indicates an acute HBV ... when fighting a HBV ... infected with HBV ... the two tests commonly ... run in the clinical
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Clinical Presentation ... symptoms - most common ... Mycoplasma, EBV, HIV ... hemolytic #anemia #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Common Variable ... to 8 years Clinical ... cancers: Most common ... DDX - Other causes ... Epstein-Barr syndrome, HIV
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Drug Associated (Commonly ... to exclude are infections ... Cryoglobulins • HIV ... • HBV HCV • ... differential #diagnosis #rheumatology
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
of the spinal cord ... • Infectious: ... sensory changes - Common ... parainfluenza, Coxsackie, HIV ... Differential #Diagnosis #neurology
Lesions of the Spinal cord - Spinal Cord Syndromes Spinal cord lesions can result in permanent neurologic
result in permanent neurologic ... Infarction - Infection ... syphilis, and HIV ... anesthesia (more commonly ... anesthesia (more commonly
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Direct microbial infection ... Transverse Myelitis - Clinical ... simplex virus, HIV ... - Sjogren - Vasculitis ... diagnosis #management #neurology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Nodosa: • PAN most commonly ... affects the skin, neurologic ... HTN • Check: HBV ... drug exposure or Dx ... Differential #Diagnosis #Rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
malignancies, vasculitis ... Malignancy • Infections ... Cryofibrinogenemia DDX ... • TTP, HUS and HIT ... Cryofibrinogenemia #diagnosis #rheumatology
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