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diagnosis hematology differential anemia management agglutinin aplastic classification cold cryofibrinogenemia cryoglobulinemia cryoglobulins disease hemolytic monoclonal myelitis paraproteinemias transverse types
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... : HCV infection, ... HBV infection, ... HIV infection ... classification #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... - Due to Viral infection ... Clinical Presentation ... Mycoplasma, EBV, HIV ... hemolytic #anemia #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia Clinical ... - CMV - HCV ... - HIV • Immune ... and thymoma DDX ... immunodeficiency virus (HIV
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Direct microbial infection ... Transverse Myelitis - Clinical ... simplex virus, HIV ... - Sjogren - Vasculitis ... diagnosis #management #neurology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
affects the skin, neurologic ... HTN • Check: HBV ... cognitive impairment, neurologic ... drug exposure or Dx ... Differential #Diagnosis #Rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
malignancies, vasculitis ... Malignancy • Infections ... Diagnosis: • + Clinical ... Cryofibrinogenemia DDX ... • TTP, HUS and HIT
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Zone Lymphoma (HCV ... et diutinum Neurologic ... Autoimmunity: • -MM/WM: Vasculitis ... anemia due to cold ... Differential #Diagnosis #Oncology
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