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oncology management erythematosus globulin lupus lymphocytic mds monoclonal myelodysplasia myelodysplastic paraproteinemias proteingap sle symptoms vasculitis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can indicate disease ... • Richter’s Syndrome ... syndrome • Smoldering ... #diagnosis #workup ... #oncology #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... any age) Autoimmune ... SLE • Mikulicz syndrome ... Syndrome Diagnosis ... #Syndrome #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome ... Systemic disease ... disease) Differential ... #Syndrome #diagnosis ... #symptoms #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
syndrome, and mixed ... rheumatologic diseases ... lymphoma • Evans' syndrome ... Shrinking lung syndrome ... #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... capillary leak syndrome ... Evans • ITP • Cl-NH ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
• Heavy chain disease ... changes (POEMS syndrome ... Sarcoidosis) • Liver disease ... gastric tumors • Hematology ... diagnosis #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Marrow Failure • Chronic ... Cell Leukemia ... Myeloproliferative Disease ... blood count with differential ... #diagnosis #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis: • Systemic ... Mucocutaneous lymph node syndrome ... syndrome: Recurrent ... vasculitis • Cogan syndrome ... #Diagnosis #Rheumatology
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