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hematology antibodies antinuclear bee causes cryoglobulinemia cryoglobulins high hyperkalemia hypocomplementemia low mnemonic monoclonal myositis neurology oncology paraproteinemias potassium size sle
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... #patterns #rheumatology ... #diagnosis #differential
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
small vessels - ANCA-associated ... Churg-Strauss syndrome ... lupus erythematosus ... - Sjögren syndrome ... #Diagnosis #Rheumatology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
less common diseases ... Vogt-Koyanagi-Harada (VKH) disease ... • Systemic lupus ... polychondritis • Behcet disease ... spectrum disorder • ANCA-associated
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... Diagnosis: • ANCA-associated ... rheumatologic diseases ... Shrinking lung syndrome ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Mucocutaneous lymph node syndrome ... : • Behçet Syndrome ... • Cogan Syndrome ... lupus erythematosus ... differential #diagnosis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Chain deposition disease ... Atypical HUS, autoimmune ... antiphospholipid syndrome ... Lupus Erythematosus ... #diagnosis #differential
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... diseases: - 10% ... 20% Sjögren's syndrome ... DDX: • ANCA (Antineutrophil ... lupus erythematosus
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... capillary leak syndrome ... Hyperviscosity syndrome ... (Dermato-neuro syndrome ... Sneddon-Wilkinson disease
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Antisynthetase syndrome ... or head drop • ANA ... ANTI-SYNTHETASE SYNDROME ... paraneoplastic syndrome ... differential #diagnosis
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
: syßtemic lupus ... Chronic kidney disease ... Chronic kidney disease ... End-stage renal disease ... antiphospholipid syndrome
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