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diagnosis differential management dermatology classification druginduced erythematosus hydroxychloroquine pharmacology vasculitis benefits clues comparison cryoglobulinemia cryoglobulins dil levels measurement nonpalpable palpable
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... half-life = 40 days ([HCQI ... #Measurement #SLE ... #rheumatology # ... pharmacology #levels #lupus
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Manifestations: Malar rash ... , oral ulcers, Lupus ... Positive in 60-80% of cases ... Management #Summary #rheumatology
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions - Inflammatory
Vesiculobullous Skin Rash ... Differential Diagnosis Algorithm ... Bullous systemic lupus ... Vesiculobullous #SkinRash ... #causes
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... NPSLE rare, Malar rash ... Discontinuation of causal ... Manifestations: Malar rash ... #table #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Differential Diagnosis Algorithm ... Anemia • Toxic Damage ... Autoimmune • ITP • SLE ... #Causes #Hematology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
everywhere) 2) A rash ... 6) An annular rash ... children (pediatric SLE ... #diagnosis #sle ... erythematosus #rheumatology
Hydroxychloroquine - Risks and Benefits in Lupus Benefits: ↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
and Benefits in Lupus ... activity, ↓ Flare, ↓ Damage ... Hydroxychloroquine #hcq ... #pharmacology #adverseeffects ... #sideeffects #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Splenomegaly - CTD (SLE ... Associated - SLE ... • HCV, HBV Not ... Differential #Diagnosis #hematology ... #rheumatology #
Papulosquamous Skin Rash - Differential Diagnosis Algorithm Erythrematous or violaceous papules & plaques with overlying scale •
Papulosquamous Skin Rash ... Differential Diagnosis Algorithm ... soles • Discoid Lupus ... Papulosquamous #SkinRash ... #causes
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Infections: HCV ... (e.g. systemic lupus ... classification #rheumatology
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