15 results
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Polyangiitis (GPA ... polyangiitis (GPA ... GPA causes disease ... #Polyangiitis #GPA ... #dermatology #rash
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... Kasabach-Merritt syndrome ... vasculitis - GPA ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... RA, Sjogren's, GPA ... deficiency Work ... cryoglobulins • Skin ... #Causes #dermatology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Look for gamma gap ... Causes of false- ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology ... #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Albumin > 4) Work-up ... gammopathy, and skin ... changes (POEMS syndrome ... gastric tumors • Hematology ... differential #diagnosis #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• CLL & MBL • Heavy ... Alpha & Mu) Skin ... Pseudohyponatremia • ↓anion gap ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... - Purpura - Skin ... Cryoglobulins Cause ... : • Clinical triad ... associated vasculitis - GPA
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
> PR3 60% • GPA ... in >80% (80-90% have ... tract, and often causes ... • Cogan Syndrome ... • ANCA (Dx: GPA
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia Clinical ... Headaches • Pale skin ... and petechiae Causes ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... just beneath the skin ... • Exposure to heavy ... #diagnosis #hematology ... #oncology