6 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... light chain vs. heavy ... #Significance #MGUS ... Differential #Diagnosis #hematology ... #oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Monoclonal Gammopathy ... immunoglobulin heavy-chain ... #Monoclonal #Gammopathy ... #Significance #hematology ... #diagnosis #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Albumin > 4) Work-up ... Include: • MGUS ... Connective tissue disorders ... gastric tumors • Hematology ... differential #diagnosis #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• MM • WM • MGUS ... • CLL & MBL • Heavy ... Pseudohyponatremia • ↓anion gap ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
due to a lack of GP ... MYH9-Related Disorder ... non-muscle myosin heavy ... Platelet #Defects #comparison ... differential #diagnosis #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... • Exposure to heavy ... Syndromes #diagnosis #hematology ... #oncology