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diagnosis differential cell chronic gammopathy gap globulin leukemia lymphocytic management mds myelodysplasia myelodysplastic paraproteinemias plasmacytoma protein proteingap significance solitary syndromes
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
disorder characterized ... immunoglobulin heavy-chain ... to the plasma cell ... #Significance #hematology ... #diagnosis #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Can Feature A Monoclonal ... Lymphoma (HCV) • CLL ... & MBL • Heavy ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... leukemia in adults • Disorder ... fludarabine) 3) Monoclonal ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Gammopathy Include: • MGUS ... Connective tissue disorders ... gastric tumors • Hematology ... differential #diagnosis #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Workup: • Complete ... Syndromes #diagnosis #hematology ... #oncology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Biopsy: Solitary disorder ... tissue composed of monoclonal ... #Plasmacytoma #Oncology ... #Diagnosis #Workup ... #Hematology
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