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diagnosis differential cell chronic gammopathies gammopathy gap globulin hemeonc leukemia lymphocytic management mds multiplemyeloma myelodysplasia myelodysplastic paraproteinemias plasmacytoma proteingap significance
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
disorder characterized ... immunoglobulin heavy-chain ... to the plasma cell ... #Significance #hematology ... #diagnosis #oncology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma and Monoclonal ... gamma gap (total protein ... #Gammopathies #MGUS ... #diagnosis #hematology ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Protein/M Component ... • MM • WM • MGUS ... Lymphoma (HCV) • CLL ... & MBL • Heavy ... Paraproteinemias #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Gammopathy Include: • MGUS ... Connective tissue disorders ... gastric tumors • Hematology ... differential #diagnosis #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... leukemia in adults • Disorder ... fludarabine) 3) Monoclonal ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Workup: • Complete ... Syndromes #diagnosis #hematology ... #oncology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Biopsy: Solitary disorder ... tissue composed of monoclonal ... #Plasmacytoma #Oncology ... #Diagnosis #Workup ... #Hematology
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