5 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... History of bleeding (petechiae ... hematemesis, melena, heavy ... Diagnosis #Causes #Workup ... #hematology
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
due to a lack of GP ... MYH9-Related Disorder ... non-muscle myosin heavy ... #Defects #comparison ... differential #diagnosis #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Thrombocytopenia - Abnormal platelet ... Vasculitis - Collagen disorders ... RA, Sjogren's, GPA ... deficiency Work ... Algorithm #Causes #dermatology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... caused by bleeding (petechiae ... • Exposure to heavy ... Syndromes #diagnosis #hematology ... #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Albumin > 4) Work-up ... Gammopathy Include: • MGUS ... Connective tissue disorders ... gastric tumors • Hematology ... differential #diagnosis #hematology