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oncology leukemia management chronic hemolytic lymphocytic aplastic causes cold disease extravascular hemolysis heparin hit induced infectiousdiseases intravascular mds mycobacteria myelodysplasia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Syndrome (CAS): ... Clinical Presentation ... anemia • Cold ... younger pts) Differential ... #hematology #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... . primary cold agglutin ... Extravascular #Causes #differential ... #diagnosis #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... , thrombocytopenia ... -> Invade Skin: ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... immunophenotype Clinical ... Complications: 1) Infection ... Leukemia #oncology #hematology ... #hemeonc #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
weeks without infection ... Hepatomegaly • Skin ... • Neutropenia, anemia ... , thrombocytopenia ... workup #oncology #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... purple, hemorrhagic skin ... - Hemolytic anemia ... #Diagnosis #hematology ... #nonpalpable #dermatology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
necrosis (at injection ... ♀, ↑Age, ESRD Pathophysiology ... Clinical Suspicion ... #Treatment #Hematology ... #HemeOnc
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... Headaches • Pale skin ... /fevers • Thrombocytopenia ... #oncology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
platelet count (thrombocytopenia ... just beneath the skin ... • Parvovirus infection ... blood count with differential ... #diagnosis #hematology
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Lady Windermere Syndrome ... : • Syndrome of ... Hematologic malignancy ... Bone Marrow - Anemia ... #differential #
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