12 results
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
in Sickle Cell Disease ... predispose to other orthopedic ... Osteomyelitis / Septic Arthritis ... #differential # ... diagnosis #causes #hematology
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
Symptoms of Joint Disease ... categories of joint disease ... #MSK #rheumatology ... #approach #workup ... #differential #
Septic Arthritis - Diagnosis and Management Summary
Clinical Exam: hot, swollen, pain with passive AND active ROM
Diagnosis and Management ... hot, swollen, pain ... necrosis, Lyme disease ... Workup: arthrocentesis ... parenteral Abx, Orthopedics
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
) Differential Diagnosis ... SLE, Reactive arthritis ... Nonsurgical abdominal pain ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
juvenile idiopathic arthritis ... • Fever is the main ... with leukopenia, anemia ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Approach to Joint Pain ... ), RA, crystal disease ... #rheumatology # ... approach #workup ... #differential #
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Studies in Rheumatic Diseases ... the presence of anemia ... , and low back pain ... #laboratory #workup
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Malignancy (e.g. hematologic ... : • Joint pain ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
very remarkable w/differential ... systemic complaints- anemia ... claudication: pain ... chews, not just pain ... Symptoms #Diagnosis #Management
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Pain in LN ... Hodgkin Lymphoma Workup ... number of sites of disease ... classification #hematology ... #oncology #management