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algorithm obstetrics causes cholangitis cirrhosis comparison disease injury liverenzymes management obgyn primary workup
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Pruritus, Mild jaundice ... Hepatic infarcts, Hematomas ... Liver of Pregnancy ... diagnosis #icp # ... HELLP #AFLP
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... of Pregnancy (AFLP ... (DIC, ascites, jaundice ... #Fatty #Liver # ... Pregnancy #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Wilson's • Pregnancy ... - AFLP, HELLP ... Duct Stone • Biliary ... • Others #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
, PBC, PSC, IgG4 ... melanoma, myeloma • Pregnancy ... : HELLP • Iatrogenic ... hemolysis, bleeding, hematoma ... #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Pathophysiology ... hyperpigmentation • Jaundice ... Viral hepatitis, ... cholestasis of pregnancy ... #workup #hepatology
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