247 results
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
(ALT or AST > ALP ... Wilsons, Pregnancy - AFLP ... Cholestatic Pattern (ALP ... Congenital, Others, Cirrhosis
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... infiltrates maternal hepatocytes ... iMedEducation #AFLP
Coagulation management in the bleeding cirrhotic
#Management #INR #Coagulopathy #Cirrhosis #Cirrhotic #TEG #Transfusions
in the bleeding cirrhotic ... #Coagulopathy #Cirrhosis ... #Cirrhotic #TEG
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Synthesis: in hepatocyte ... accumulation in hepatocyte ... from albumin upon hepatocyte ... conjugation in hepatocyte ... reuptake into hepatocyte
Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
specimens: ballooned hepatocytes ... distribution of NASH, cirrhosis ... NonAlcoholicFattyLiverDisease #Cirrhosis
Pathogenesis of Cirrhotic Ascites

#ascites #pathophysiology #hepatology #cirrhosis
Pathogenesis of Cirrhotic ... pathophysiology #hepatology #cirrhosis
Pathology - Hepatocyte Pigments

Lipofuschin (H&E) 

Alpha-I-antitrypsin globules (PAS-D) 

Mallory's hyaline / Mallory Denk Bodies 

Giant Mitochondria
Pathology - Hepatocyte ... bilirubinostasis (H&E) #Hepatocyte
Management of critically-ill cirrhotic patients

Open Access Source (Intensive Care Med (2018) 44:1932–1935): https://link.springer.com/epdf/10.1007/s00134-018-5078-z?shared_access_token=rKBIIjC6Htq14G82yghJnfe4RwlQNchNByi7wbcMAY63FIMr4IeFUPHZTUFKckgGIQeEsXu7k1NhPo-T8ItytjuWlMH7y0kI6IydY2i7VzU4Y93MfuEKQruo-qIKnVF91JyuQsQbJNPJv3UJYPzkySdSktYPmFVd6xw1xJDLPqY%3D

#cirrhotic #cirrhosis #Management #CriticalCare
critically-ill cirrhotic ... rKBIIjC6Htq14G82yghJnfe4RwlQNchNByi7wbcMAY63FIMr4IeFUPHZTUFKckgGIQeEsXu7k1NhPo-T8ItytjuWlMH7y0kI6IydY2i7VzU4Y93MfuEKQruo-qIKnVF91JyuQsQbJNPJv3UJYPzkySdSktYPmFVd6xw1xJDLPqY%3D #cirrhotic ... #cirrhosis #Management
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
• Pregnancy - AFLP ... Infiltrative • Cirrhosis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
(Alk phos/ULN ALP ... • AST/ALT > ALP ... Cholestasis • ALP ... disease • If ALP ... hepatitis: < 1 • Cirrhosis