14 results
Causes of Hepatomegaly and Splenomegaly in children

#Hepatomegaly #Splenomegaly #Hepatosplenomegaly #HSM #Differential #Causes #Peds #Pediatrics
#Splenomegaly #Hepatosplenomegaly
Congenital Infections - Comparison Table:
Infections: Toxoplasma, Rubella, CMV, Treponema, Parvovirus B19, VZV, Herpes, Enterovirus
Manifestations: Anemia, Bony
Hearing impairment, Hepatosplenomegaly
High Output Heart Failure - Pathophysiology and Differential Diagnosis
Obesity - Systemic Vasodilation, Vasoactive Adipokines
Arteriovenous Fistula -
Disorders - With Hepatosplenomegaly
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
• Usually no hepatosplenomegaly ... lymphadenopathy, mass, Hepatosplenomegaly
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Xanthomas • Hepatosplenomegaly
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Clinical: fever +++, hepatosplenomegaly
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Nonremitting fever • Hepatosplenomegaly
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
lymphadenopathy, or hepatosplenomegaly
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework

Viral Encephalitis:
MCC: Enteroviruses (e.g., coxsackievirus
Lymphadenopathy • Hepatosplenomegaly
Chagas Disease - American Trypanosomiasis - Diagnosis and Management Summary
Chagas disease (American trypanosomiasis) is an infectious
malaise, fever, hepatosplenomegaly