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diagnosis hepatology abnormal aptt coagulation hematology prolonged algorithm alkaline alp biliary cholangitis cirrhosis disease elevation hellp hepatitis icp obstetrics pbc
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
extensive necrosis and hemorrhage ... of Pregnancy (AFLP ... often <5 mg/dL, higher ... obstetrics #hepatitis #comparison ... #differential #
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
) Elevation - Differential ... phosphatase sources: - Highest ... • Bone • Liver ... Intestine - Other causes ... elevation DDX of Hepatic
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... (e.g. heparin contamination ... thrombin inhibitors, heparin ... • Reduced liver ... • Massive hemorrhage
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... Massive hemorrhage ... #diagnosis #differential
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... obstruction • ALP ... titer 1:40 or higher ... bile ducts Differential ... malignancies, Hepatic
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